Metformine

[sabulle]

le cyanoguanidine est-il un produit de dégradation du metformine merci ciao
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[shaddock91]

le cyanoguanidine est-il un produit de dégradation du metformine merci ciao

Tu recherche sur Google
metformine cyanoguanidine

Beaucoup de références à consulter. Bon courage

[sabulle]

merci pour votre aide précieuse .a votre avis où cherche -t-on en premier quand on cherche un truc sur le net ciao

[sabulle]

Many of the biguanides have oral hypoglycemic
activity, and metformin (87) is such an antidiabetic
agent. Cyanamide has a highly reactive nitrile
function because of the electropositive NH2 group
Aliphatic Compounds 21
attached and at pH 8-9 self-adds to form "dicyanamide"
(86, for which cyanoguanidine would be a better
22
name). Fusion with dimethylamine leads efficiently
to metformin (87) by addition to the nitrile function.
23
Metformin is closely related to buformin.
The discovery and clinical acceptance of
meprobamate, and the relative chemical accessibility
of this group of compounds has led to intensive
exploration of 1,3-biscarbamates. It was found that
2 NH2CN ---- NCNHCNH2 ------(CH3)2NCNHCNH

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