Protéine: P1-P1'
Bonjour à tous,
Voilà j'aimerais savoir car quand je lis des articles sur les protéines je vois toujours P1, P2, P3, ... comment je sais à quoi ça correspond dans ma protéine?
Je pense que j'ai juste compris que P1-P'1 était un 'peptide bond'...
Merci d'avance,
Bien à vous,
ok j'ai trouvé
http://guweb2.gonzaga.edu/faculty/cr...ition=protease
Nomenclature for endopeptidase substrates
A system of nomenclature for protease substrates is a helpful adjunct to discussion of protease mechanism and specificities. On the N-terminal side of the scissile bond, the residues of the substrate are denoted as P1, P2, P3,..., etc., in the C-to-N direction. On the C-terminal side of the scissile bond, the residues of the substrate are denoted P1′, P2′, P3′,..., etc., in the N-to-C direction.
Specificity of proteases can be based on recognition of substrate residues in the P1, P2, P3,..., and P1′, P2′, P3′,..., etc., positions. The sites on the enzyme where these substrate residues are bound are designated using a corresponding nomenclature: The S1 site (or S1 pocket) of the enzyme is where the side chain of the P1 residue is accomodated. Other sites on the enzyme are named in similar fashion.
